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Animal Tablets

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Biotech->Biochemistry->veterinary medicine

Product Specification

Model No:	Animal Tablets

Country	CN

Product Detail

Albendazole 300 mg. bolus
(Item No.: TB002)

Composition:
Contains per bolus.:
Albendazole......................................................300 mg
Carrier ad.......................................................... 4 g
Description:
Albendazole is a synthetic anthelmintic which belongs to the group of benzimidazole-derivatives with activity against a broad range of worms and at a higher dosage level also against adult stages of liver fluke.
Indications:
Prophylaxis and treatment of worminfections in cattle, calves, sheep and goats like:
Gastrointestinal worms: Bunostomum, Cooperia, Chabertia, Haemonchus,
Nematodirus, Oesophagostomum, Ostertagia, Strongyloides and Trichostrongylus spp.
Lung worms: Dictyocaulus viviparus and D. filaria.
Tapeworms: Monieza spp.
Liver-fluke: adult Fasciola hepatica.
Dosage:
For oral administration.
Calves and cattle: 1 bolus per 60 kg. body weight.
For liver-fluke: 1 bolus per 35 kg. body weight.
Sheep and goats: 1 bolus per 35 kg. body weight.
For liver-fluke: 1 bolus per 30 kg. body weight.
Contra indications:
Administration in the first 45 days of gestation.
Side effects:
Hypersensitivity reactions.
Withdrawal times:
For meat: 12 days.
For milk: 4 days.
Warning:Keep out of reach of children.
Levamisole 150mg bolus

(Item No.: TB004)

Composition:
Contains per bolus.:
Albendazole......................................................150 mg Carriere ad 6g
Albendazole......................................................600 mg Carriere ad 6g
Albendazole......................................................1000 mg Carriere ad 6g
Pharmacology
Levamisole is an imidazothiazole that acts by interfering with parasite nerve transmission causing muscular paralysis. It stimulates the parasympathetic and sympathetic ganglia in susceptible worms. At higher levels, levamisole interferes with nematode carbohydrate metabolism by blocking fumarate reduction and succinate oxidation. The net effect is a paralyzing effect on the worm which is then expelled alive. Levamisole's effects are considered to be nicotine-like in action.
Pharmacokinetics
Levamisole is absorbed from the gut after oral dosing and through the skin after dermal application, although bioavailabilities are variable. It is reportedly distributed throughout the body. Levamisole is primarily metabolized with less than 6% excreted unchanged in the urine. Plasma elimination half-lives have been determined for several veterinary species: Cattle 4-6 hours; Dogs 1.8-4 hours; and Swine 3.5-6.8 hours. Metabolites are excreted in both the urine (primarily) and feces.
Indications
Levamisole is indicated for the treatment of many nematodes in cattle, sheep & goats, swine, poultry. In sheep and cattle, levamisole has relatively good activity against abomasal nematodes, small intestinal nematodes (not particularly good against Strongyloides spp.), large intestinal nematodes (not Trichuris spp.), and lungworms. Adult forms of species that are usually covered by levamisole, include: Haemonchus spp., Trichostrongylus spp., Osteragia spp., Cooperia spp., Nematodirus spp., Bunostomum spp., Oesophagostomum spp., Chabertia spp., and Dictyocaulus vivapurus. Levamisole is less effective against the immature forms of these parasites and is generally ineffective in cattle (but not sheep) against arrested larval forms.
In swine, levamisole is indicated for the treatment of Ascaris suum, Oesophagostomum spp., Strongyloides, Stephanurus, and Metastrongylus.
Levamisole has been used in dogs as a microfilaricide to treat Dirofilaria immitis infection.
Contraindications/PrecautionsLevamisole is contraindicated in lactating animals. It should be used cautiously, if at all, in animals that are severely debilitated, or have significant renal or hepatic impairment. Use cautiously or, preferably, delay use in cattle that are stressed due to vaccination, dehorning or castration. There is no information regarding the safety of this drug in pregnant animals. Although levamisole is considered relatively safe to use in large animals that are pregnant, use only if the potential benefits outweigh the risks.
Adverse Effects/Warnings
Adverse effects that may be seen in cattle can include muzzle-foaming or hypersalivation, excitement or trembling, lip-licking and head shaking. These effects are generally noted with higher than recommended doses or if levamisole is used concomitantly with organophosphates. Symptoms generally subside within 2 hours. When injecting into cattle, swelling may occur at the injection site. This will usually abate in 7-14 days, but may be objectionable in animals that are close to slaughter.
In sheep, levamisole may cause a transient excitability in some animals after dosing. In goats, levamisole may cause depression, hyperesthesia and salivation.
In swine, levamisole may cause salivation or muzzle foaming. Swine infected with lungworms may develop coughing or vomiting.
Adverse effects that may be seen in dogs include GI disturbances (usually vomiting, diarrhea), neurotoxicity (panting, shaking, agitation or other behavioral changes), agranulocytosis, dyspnea, pulmonary edema, immune-mediated skin eruptions (erythroedema, erythema multiforme, toxic epidermal necrolysis) and lethargy.
Adverse effects seen in cats include hypersalivation, excitement, mydriasis and vomiting.
Dosage and Administration
For oral administration. The general dosage is 5-7.5 mg Levamisole per kg bodyweight.
For more specific details relating to each bolus, see table below.
Bolus Dosage
150mg 1 bolus per 25kg body weight
600mg 1 bolus per 100kg body weight
1000mg 1 bolus per 150kg body weight
Withdrawal PeriodCattle (meat & offal): 5 daysSheep (meat & offal): 5 daysNot to be used in animals producing milk for human consumption.
Storage
The recommended maximum storage temperature is 30℃.Warning：Keep out of reach of children.

Tetramisole 300 mg
(Item No.: TB007)
Composition:
Each bolus contains:
Tetramisole Hcl…………………………………………300 mg
Carriere ad ………………………………………………….5g
Description:
Tetramisole is indicated for the treatment like Haemonchus sp, Ostertagia spp, Trichostrongylus spp, Nematodirus sp, Bunostomum spp, Oesophagostomum spp, Cooperia sp, Dictyocaulus sp, Ascaris suum, Strongyloides ransomi; Metastrongylus spp, Oesophagostomum sp, Ascaridia spp and Capillaria. Within 24 hours therapeutic blood levels are obtained. Tetramisole is mainly excreted in urine.
Indication:
Tetramisole is intended for the treatment of different worm infection in cattle,swine and poultry; Dictiocaulosis, Haemonchosis, Bunostomosis, Oesophagostomiasis, Nematodirus, Cooperiosis, Strongyloidiasis, Ascaridosis, Oesophagostomiasis, Strongyloides, Trichocephalus, Metastrongilosis, Ascaridosis, Capillariasis, Heteracidosis and Singamoz.
Dosage and Administration:
For oral administration:
Cattle & sheep; 1 bolus per 30 kg body weight
Swine; 1 bolus per 25 kg body weight
Poultry; 1 bolus per 10-20 kg body weight
Side Effects:
No undesirable effects are to be expected when the prescribed dosage regimen is followed.

Contra-indication:
- Administration to infections.
- Administration to last third period of gestation.
- Administration to animal with an impaired liver function.
- Administration to animal with an impaired renal function.
- Concurrent administration of Pyrantel, Morantel or organ-phosphates.
Withdrawal Period:
For meat; 7 days
For milk; 2 days
Packing:
100 boluses (300 mg)
Storage condition:
Store in a cool, dry and dark place, below 30°C
Warning: keep out of the children

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