Bulk Cinnamon Bark Powder Extract->active pharmaceutical ingredient

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Bulk Cinnamon Bark Powder Extract

Category :

Chemicals->active pharmaceutical ingredient

Product Specification

Model No:	C011.R02000

Country	CN
Brand	OHI
Packing	Drum, Plastic Container, Vacuum Packed, OEM Services Provide
Minimum Order	1
Payment Term	L/C,T/T,D/P,Money Gram,Western Union

Product Detail

Cinnamon as the name of several species of evergreen aromatic tree that belonging to the genus Cinnamomum in the family Lauraceae and the commercial spice products that made by the bark of a few of them.One economically important specie of the genus is Cinnamomum cassia, commonly called Chinese cassia or Chinese cinnamon, is an evergreen tree originating in southern China, and widely cultivated there and elsewhere in southern and eastern Asia (India, Indonesia, Laos, Malaysia, Taiwan, Thailand, and Vietnam).The tree grows to 10-15 m tall, with greyish bark and hard, elongated leaves that are 10-15 cm long and have a decidedly reddish colour when young.


In additionto it wide application in foods ,Cinnamon ,also called Cortex Cinnamomi Cassiae,is used in China for a long time as a fundamental herbs in traditional Chinese medicine.


 

<h2>
Basic Information of Cinnamon Bark Extract (No Coumarin)
</h2>
<ul>
<li>
Name : Cinnamon Bark Extract (no coumarin)
</li>
<li>
Source: Cortex Cinnamomi Cassiae
</li>
<li>
Botanical Name : Cinnamomum cassia
</li>
<li>
Extract part: Bark
</li>
<li>
Composition Ratio : 10 to 1, polyphenols 10%20%40%
</li>
<li>
Appearance: Fine Brownish red powder
</li>
<li>
Country of origin: P.R. China
</li>
</ul>
<h2>
Functions: 
</h2>

Antidepressant 
Antidepressive activity of Cinnamomum cassia compound Cinnamomum cassia was investigated by oral gavage administration to stressed rats for 21days .Study result published on Journal of Ethnopharmacology showed that chronic unexpected mild stress (CUMS) procedure not only decreased the sucrose preference, but also elevated the COX-2 activity, mRNA and protein levels, and increased PGE2 concentration in rat brain regions. Treatment with high doses of cinnamic aldehyde (45, 90 mg/kg) reversed the behavioral abnormalities, and decreased the COX-2 protein and activity (but not COX-2 mRNA expression) and PGE2 concentration in frontal cortex and hippocampus of stressed rats.The current findings suggest that targeting COX-2 system might be benefit to the depression, especially elderly individuals and cinnamic aldehyde might be a promising medicine to treat the subjects in the depression.


anti-inflammatory 
Investigation conducted in 2012 examined the anti-inflammatory effects of Cinnamomum cassia constituents (cinnamic aldehyde, cinnamic alcohol, cinnamic acid, and coumarin) using lipopolysaccharide (LPS)-stimulated mouse macrophage (RAW264.7) and carrageenan (Carr)-induced mouse paw edema model. Result showed on Evid Based Complement Alternat Med indicated that Cinnamic aldehyde decreased the NO, TNF-α, and PGE2 levels on the serum level after Carr injection. Western blotting revealed that cinnamic aldehyde decreased Carr-induced iNOS, COX-2, and NF-κB expressions in the edema paw. These findings demonstrated that cinnamic aldehyde has excellent anti-inflammatory activities and thus has great potential to be used as a source for natural health products.


Antioxidative 
In an early experiment reported on Phytother Res determined the wound healing action of an ethanol extract of cinnamon, researchers suggested the significant increase in wound healing was attributable to the antioxidant activity demonstrated.Further study showed on Biofactors in 2006 that the effects of Cinnamomum cassia the activity of the antioxidant enzymes (catalase, superoxide dismutase and glutathione peroxidase) in the liver of db/db mice were demonstrated .Study showed Cinnamomum cassia extracts significantly decreased on blood glucose, increased levels of reduced glutathione and the activities of glutathione reductase, glutathione S-transferase, glutathione peroxidase, catalase and superoxide dismutase in the liver.

Antihyperglycemic and antihyperlipidemic

Nowadays, increased oxidative stress was shown to play an important role in the etiology and pathogenesis of diabetes mellitus and its complications. A study reported on Biofactors showed that Cinnamomum cassia extracts significantly decreased blood glucose, lipid peroxidation and increased the level of reduced glutathione.Such findings suggest Cinnamomum cassia may be effective for correcting hyperglycemia and preventing diabetic complications.And further study released on Arch Pharm Res in 2010 scientists explored their mechanism of action. The results suggest that cinnamon extract significantly increases insulin sensitivity, reduces serum, and hepatic lipids, and improves hyperglycemia and hyperlipidemia possibly by regulating the PPAR-medicated 
glucose and lipid metabolism.


Antibacterial 
Biochem Biophys Res Commun . 1997 
In vitro inhibition of bacterial endotoxin has been demonstrated by an unidentified component in cinnamon bark. 36 The essential oils of cinnamon halted mycelial growth and aflatoxin synthesis in Aspergillus parasiticus at a concentration of only 0.1%. 37 
 
Food Chem Toxicol . 2002; 
Essential oils of 12 medicinal plants were tested for inhibitory activity against Aspergillus flavus, A. parasiticus, A. ochraceus and Fusarium moniliforme. The oils of thyme and cinnamon (⩽500 ppm), marigold (⩽2000 ppm), spearmint, basil, quyssum (3000 ppm) completely inhibit all the test fungi. Caraway was inhibitory at 2000 ppm against A. flavus, A. parasiticus and 3000 ppm against A. ochraceaus and F. moniliforme. A. flavus, A. ochraceus, A. parasiticus and F. moniliforme were completely inhibited by anise at⩽500 ppm. However, chamomile and hazanbul at all concentrations were partially effective against the test toxigenic fungi. The results indicate that the test toxigenic fungi are sensitive to the 12 essential oils, and particularly sensitive to thyme and cinnamon. The results also showed that the essential oils of thyme, cinnamon, anise and spearmint have more effect on fungal development and subsequent mycotoxin production in wheat grains. The extent of inhibition of fungal growth and mycotoxin production was dependent on the concentration of essential oils used.


Anticancer 
Lung Cancer 
An investigation published on J Altern Complement Med in 2000 that cinnamon bark ,as a part of a traditional herbal medicines showed activities against lung carcinoma .The tumor marker levels (CEA and CA19-9) decreased and the scores of yin-yang and xu-shi inverted from negative and positive during 7 weeks. The patient's cough disappeared and her appetite recovered.NYT has a positive effect on life expectancy for patients with malignancy. The diagnostic scoring system in yin-yang and xu-shi and prescription of Chinese herb may be available to gain control over a patient's health.

<h2>
Product application
</h2>

Cinnamon is used as a spice and aromatic. Traditionally, the bark or oil has been used to combat microorganisms, diarrhea, and other GI disorders, and dysmenorrhea, although there is limited data to support these uses.Cinnamon has found multiple activities including anti-inflammatory, antioxidant, and antimicrobial activity ,it also have potential applications in the management of diabetes.


In foods, cinnamon is used as a spice and as a flavoring agent in beverages.


In manufacturing, cinnamon oil is used in small amounts in toothpaste, mouthwashes, gargles, lotions, liniments, soaps, detergents, and other pharmaceutical products and cosmetics.


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