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Ropivacaine HCL api and intermediate cas 132112-35-7 

  Category : Chemicals->Pharmaceutical->pharmaceutical

     
Ropivacaine HCL api and intermediate cas 132112-35-7
       

  Product Specification
 
  Country  CN

 

    Product Detail
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Product: Ropivacaine hydrochloride
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CAS NO.: 132112-35-7
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Standard: BP,CP,USP
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Molecular Formula: C17H26N2O.ClH.H2O
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Molecular Weight: 328.88
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Description: White crystal or crystalline powder
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Package: 25KG/drums
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Chemical names, synonyms:
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Ropivacaine Hydrochloride (200 mg)
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1-methy1-1h-tetrazol-5-ylthiol
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Ropivacaine Hcl monohydrate
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Ropivacaine Hydrochloride, USP
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Ropivacaine-(S) Hydrochloride
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Ropivacaine HCl.H2O
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Ropivacaine hydrochloride hydrate
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LEA-103 HCl
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Minimum purity: 99%
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<img src="http://i.bosscdn.com/product/6c/b9/40/41d442c6197aff9b27a913cc25.gif" title="Ropivacaine hydrochloride 132112-35-7" alt="Ropivacaine hydrochloride 132112-35-7" />
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Biochem/physiol&nbsp;Actions<br />
Local&nbsp;anaesthetic&nbsp;with&nbsp;less&nbsp;cardiotoxicity&nbsp;than&nbsp;bupivacaine;&nbsp;causes&nbsp;reversible&nbsp;blockade&nbsp;of&nbsp;impulse&nbsp;propagation&nbsp;along&nbsp;nerve&nbsp;fibres&nbsp;by&nbsp;preventing&nbsp;the&nbsp;inward&nbsp;movement&nbsp;of&nbsp;sodium&nbsp;ions&nbsp;through&nbsp;the&nbsp;cell&nbsp;membrane&nbsp;of&nbsp;the&nbsp;nerve&nbsp;fibers.<br />
form&nbsp;&nbsp; powder<br />
optical&nbsp;activity&nbsp;&nbsp; [α]/D&nbsp;-9&nbsp;to&nbsp;-12,&nbsp;c&nbsp;=&nbsp;1&nbsp;in&nbsp;methanol<br />
color&nbsp;&nbsp; white&nbsp;to&nbsp;off-white<br />
solubility&nbsp;&nbsp; H2O:&nbsp;5&nbsp;mg/mL,&nbsp;clear<br />
Ropivacaine&nbsp;Hydrochloride&nbsp;is&nbsp;the&nbsp;hydrochloride&nbsp;salt&nbsp;of&nbsp;ropivacaine,&nbsp;a&nbsp;local&nbsp;anesthetic&nbsp;of&nbsp;the&nbsp;amide&nbsp;type&nbsp;with&nbsp;analgesic&nbsp;activity.&nbsp;Ropivacaine&nbsp;binds&nbsp;to&nbsp;voltage-gated&nbsp;sodium&nbsp;ion&nbsp;channels&nbsp;in&nbsp;the&nbsp;neuronal&nbsp;membrane,&nbsp;thereby&nbsp;preventing&nbsp;the&nbsp;permeability&nbsp;of&nbsp;sodium&nbsp;ions&nbsp;and&nbsp;resulting&nbsp;in&nbsp;a&nbsp;stabilization&nbsp;of&nbsp;the&nbsp;neuronal&nbsp;membrane&nbsp;and&nbsp;inhibition&nbsp;of&nbsp;depolarization;&nbsp;nerve&nbsp;impulse&nbsp;generation&nbsp;and&nbsp;propagation&nbsp;are&nbsp;blocked,&nbsp;resulting&nbsp;in&nbsp;a&nbsp;reversible&nbsp;loss&nbsp;of&nbsp;sensation.
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</p>pharmachemm.com

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