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Ibrutinib api cas 936563-96-1 Ibrutinib intermediate 

  Category : Chemicals->Pharmaceutical->pharmaceutical

     
Ibrutinib api cas 936563-96-1 Ibrutinib intermediate
       

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Chemical&nbsp;Name: Ibrutinib<br />
Molecular&nbsp;Formula: C25H24N6O2<br />
Formula&nbsp;Weight: 440.5<br />
CAS&nbsp;No.: 936563-96-1
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<img src="http://i.bosscdn.com/product/d4/b6/59/14dd119fd2cbb1d6aec7962662.gif" width="160" height="103" title="936563-96-1" alt="936563-96-1" />
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Ibrutinib&nbsp;is&nbsp;used&nbsp;to&nbsp;treat&nbsp;chronic&nbsp;lymphocytic&nbsp;leukemia,&nbsp;Waldenstrom's&nbsp;macroglobulinemia,&nbsp;and&nbsp;as&nbsp;a&nbsp;second-line&nbsp;treatment&nbsp;for&nbsp;mantle&nbsp;cell&nbsp;lymphoma,&nbsp;marginal&nbsp;zone&nbsp;lymphoma,&nbsp;and&nbsp;chronic&nbsp;graft&nbsp;vs&nbsp;host&nbsp;disease<br />
Ibrutinib&nbsp;is&nbsp;a&nbsp;kind&nbsp;of&nbsp;Bruton&nbsp;tyrosine&nbsp;kinase&nbsp;(BTK)&nbsp;inhibitor,&nbsp;it&nbsp;could&nbsp;be&nbsp;used&nbsp;for&nbsp;the&nbsp;treatment&nbsp;of&nbsp;chronic&nbsp;lymphocytic&nbsp;leukemia&nbsp;(CLL)&nbsp;and&nbsp;mantle&nbsp;cell&nbsp;lymphoma&nbsp;(MCL).&nbsp;MCL&nbsp;and&nbsp;CLL&nbsp;are&nbsp;belonged&nbsp;to&nbsp;the&nbsp;B-cell&nbsp;non-Hodgkin's&nbsp;lymphoma,&nbsp;which&nbsp;is&nbsp;difficult&nbsp;to&nbsp;cure&nbsp;and&nbsp;easy&nbsp;to&nbsp;recurrent.&nbsp;Common&nbsp;chemical&nbsp;immunotherapy&nbsp;does&nbsp;not&nbsp;have&nbsp;the&nbsp;targeting,&nbsp;often&nbsp;occurs&nbsp;3&nbsp;or&nbsp;4&nbsp;adverse&nbsp;reactions.&nbsp;Ibrutinib&nbsp;and&nbsp;B&nbsp;lymphocytes&nbsp;could&nbsp;target&nbsp;with&nbsp;BTK&nbsp;which&nbsp;is&nbsp;necessary&nbsp;for&nbsp;formation,&nbsp;differentiation,&nbsp;and&nbsp;transmission&nbsp;of&nbsp;information,&nbsp;inhibit&nbsp;BTK&nbsp;activity&nbsp;irreversibly,&nbsp;and&nbsp;inhibit&nbsp;tumor&nbsp;cell&nbsp;proliferation&nbsp;and&nbsp;survival&nbsp;effectively.<br />
Ibrutinib&nbsp;(Imbruvica)&nbsp;is&nbsp;a&nbsp;small&nbsp;molecule&nbsp;drug&nbsp;that&nbsp;binds&nbsp;permanently&nbsp;to&nbsp;a&nbsp;protein,&nbsp;Bruton's&nbsp;tyrosine&nbsp;kinase&nbsp;(BTK),&nbsp;that&nbsp;is&nbsp;important&nbsp;in&nbsp;B&nbsp;cells;&nbsp;the&nbsp;drug&nbsp;is&nbsp;used&nbsp;to&nbsp;treat&nbsp;B&nbsp;cell&nbsp;cancers&nbsp;like&nbsp;mantle&nbsp;cell&nbsp;lymphoma,&nbsp;chronic&nbsp;lymphocytic&nbsp;leukemia,&nbsp;and&nbsp;Waldenström's&nbsp;macroglobulinemia
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